Big dog hit the nail on the head a few threads ago.
No matter what 22 LR used the game is up close and personal. If I could only have 2 guns on this earth it would probably be the 12ga shotgun and a 22LR of some sort. Keep your shots close and dump as many quality bullets in the bread basket as possible. ( i wouldn't count on a one shot stop) if you have a hard time getting yotes in close (15~20meters) or are not into that much of an adrenilin overload whack 'em with a bigger stick.
Incedently I really like the Aguila stuff. They have a speedy round & a neat 22LR that has no powder, just fires on the primer compound. I need to get the SSS's yet. CCI gold dot combo, I'm drooling now. hope it's as good as the hype.
I have a buddy who hunts yotes with his Mossberg 12ga bolt slug gun. He pays a pretty penny for each harvest, however, he is quite the braggert come dear season albeit well deserved (he practiced)