As others have posted, those are normal. It's an extra step you must go through with 45ACP - sort cases by primer size. It's a nuisance if you miss some in your batch of large primer cases when running them through a progressive press set-up.
As was pointed out,those are found on the NT type ammo which are loaded to be non-toxic (lead)
Some folks have told me that the smaller primers have less "brisance" and so, ignite the powder "more gently". Supposedly the loads are then more consistent and more accurate. I dunno, I think I would need to use a machine rest in order to test that theory but I doubt that would change much for me. Still, no problem with using the cases as long as you don't try to stuff a large primer into a small hole.