I have a Ruger P-90..big hand filling pistol too..it's a blast at the range..I shot it today..perfect for 25 yards and less..I don't shoot handguns at longer ranges (range rule) or shorter distances either (another range rule) :target:
while glock wont get my vote, they are a good pistol. for a factory 45 i'd lean toward a kimber. if you weren't as concerned with caliber i personally think the browning hi power in 40s&w is the finest all purpose semi on the market.
for value probably a ruger gp-100 357 mag. and actually spending more on a better gun is a better value, at least to me. although i havent seen a bad suggestion in this thread yet.
Get one of the auto ordinance 45's or get even a used ballester molina 45. these are not bad and certainly less likely to need parts or repair than a DA semi auto. The auto ord is a knockoff copy of the 1911a1 and is a pretty good gun, I have a buddy who put sights, sear, and a group gripper on one, had fired it for a couple thousand rounds with NO problems. You can easily pick one of these up.
The ballester Molina looks like a govt model but has a bunch of internal differences.