I have a SW 686 with a 8 3/8 inch barrel.
It is the most accurate handgun I own.
Also one of the most fun to shoot. Beats up those pop cans pretty far away.
I hope someone answers your question. I just like to shootem.
I think the velocity of any of the 357's is gonna make the bad guy quite dead at home defense distances. More dead is likely not gonna matter much.