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When I ws a young & dumb kid, a friend and I used to shoot .22 lr s out of his father's .22 mag High Standard derringer. never had a safty problem but the cases split and sometimes were hard to extract. his father found out about it and gave us a "talking to" and we never did it again. it can be done but it is not the right thing to do. accuracy probably would suffer too. but that was not a problem with a derringer cause they don't have any to start with.
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peace through superior firepower
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