I used to lust after a Single Six - til a feller here at the range got me into a shooting contest. 100 yards, his 9inch-barreled Ruger vs. my cheap and sleazy little Eyetalyun Tanfoglio single action, both in .22 WMR. Target was an ammo box.
I popped it three out of five times over several cylinders full, he hit it once out of several cylinders full.
I'm not enamored of .17HMR in a revolver, but if they offer it in .17HM2, I might bite.