The NMBH has a larger, heaver frame over the New Vaquero. One exception, the anniversary .357 NMBH.
The New Vaquero is suitable for standard loads, the NMBH well handle heavy loads. New Vaquero has fixed sights, the NMBH has adjustable. The New Vaquero is a close copy of a Colt SAA, the NMBH is not.
Married men live longer than single men do, but married men are a lot more willing to die.