Ricky
What is the manufacturer of the bullet you are going to use? I can't find a 240 gr in a Hornady or Speer manual. My Sierra manual is down stairs. If the bullet is made of lead, I try to keep the velocity between 800fps and 850fps. The lower speeds keep leading of the barrel to a minimum. W231 is a great pistol powder. Unique has almost been the standard for many years. Old Unique was a pretty dirty powder. I understand the newer version is a lot cleaner. The other day I bought some Titegroup by Hodgdon. I have read several articles that claim it is great in 45Colt reloads.
Indy